免疫捕獲軍團菌檢測試劑盒

廣州健侖生物科技有限公司

主要用途：用于檢測尿樣中嗜肺軍團菌血清型1抗原，以支持軍團菌感染的診斷。

產品規(guī)格：20T/盒

存儲條件：2-30℃

免疫捕獲軍團菌檢測試劑盒

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【產品介紹】

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【公司名稱】 廣州健侖生物科技有限公司
【】    楊永漢 
【】 
【騰訊 】 2042552662
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-3室
【企業(yè)文化】

盡管，科學家們強調研究的抗原抗體癌和肺癌樣本的數量很小，在每種情況下間質HSF1激活與患者不良預后之間的強關聯確保了開展更深入的臨床調查。他們補充說，一種基于HSF1的生物標記物有可能幫助預測出哪些患者的腫瘤，尤其是早期的肺癌zui有可能發(fā)展，并有可能從更積極的治療中獲益。相反，這樣的信息還可以防止罹患不太具有侵襲性癌癥的患者經受高毒性的治療方法“過度治療”所導致的副作用。
長久以來，人們認為，DNA突變不但是癌癥，而且也是生物體進化改變的燃料，被認為是整個基因組隨機發(fā)生的罕見事件。
然而，zui近的研究表明，癌癥發(fā)展經常涉及同時產生且彼此靠近的多個突變的形成。這些基團簇突變經常被發(fā)現于染色體重排發(fā)生區(qū)域。
相關文章發(fā)表于《Cell Reports》雜志上，可能有一天會導致新的癌癥療法。根據愛荷華大學的一個生物學家和她的同事們，以及由環(huán)境衛(wèi)生科學研究所的高級助理研究員Dmitry Gordenin所的一個研究組的研究表明。
基團簇突變的形成可能是由于DNA修復的過程。
自由藝術與科學的UI學院的生物學副教授Anna Malkova指出，DNA修復途徑，被稱為斷裂誘導復制(BIR)，可以促進DNA團的突變。
“以前，我們已經表明，雙鏈DNA斷裂(這可以產生氧化，電離輻射和復制錯誤)，可以通過BIR修復，” Malkova說。
“在BIR期間，斷裂DNA的末端與另一個染色體上的相同的DNA序列配對，并啟動一個不同尋常類型的復制，和遷移泡沫一樣的行進，并與大量的單鏈DNA的積累有關，” 她說。
在本研究中，研究人員研究了遭受到烷化劑(細胞的殺傷劑)傷害的酵母細胞的BIR過程。“我們發(fā)現，BIR過程中的單鏈DNA積累容易受到導致基團簇突變形成的傷害，”文章的另一*作者、 UI博士后 Cynthia Sakofsky解釋道，“這些基團簇與在人類癌癥中發(fā)現的相似。”

Although scientists underscore the small number of antigen-antibody and lung cancer samples studied, the strong association between interstitial HSF1 activation and poor prognosis in each patient led to a deeper clinical investigation. They add that a HSF1-based biomarker may help predict which patients' tumors, especially early-stage lung cancer, are most likely to develop and may benefit from more aggressive treatment. Conversely, such information can also prevent side effects caused by "over-treatment" of patients with less aggressive cancers undergoing hyper-toxic treatments.
It has long been believed that DNA mutations are not only cancers, but also fuels of evolutionary changes in organisms, and are thought to be a rare event in which the entire genome is randomly generated.
However, recent studies show that cancer development often involves the formation of multiple mutations that are produced simultaneously and close to each other. These cluster mutations are often found in chromosomal rearrangements.
Related articles in the Cell Reports magazine may one day lead to new cancer therapies. According to a study by a biologist and her colleague at the University of Iowa and a research team led by Dmitry Gordenin, senior assistant researcher at the Institute of Environmental Health Sciences.
The formation of cluster mutations may be due to the process of DNA repair.
Anna Malkova, associate professor of biology at the Free Academy of Arts and Sciences's UI Institute, points out that the DNA repair pathway, known as fracture-inducible replication (BIR), promotes mutations in DNA clusters.
"In the past, we have shown that double-stranded DNA breaks (which can produce oxidation, ionizing radiation and replication errors) that can be repaired by BIR," Malkova said.
"During BIR, the ends of the cleaved DNA pair with the same DNA sequence on another chromosome and initiate an unusual type of replication that travels like a migrating foam and is associated with the accumulation of large quantities of single-stranded DNA," she said Say.
In this study, researchers studied the BIR process of yeast cells that were damaged by alkylating agents (cell killers). "We found that single-stranded DNA accumulation during BIR is vulnerable to damage caused by cluster mutations," explained Cynthia Sakofsky, UI postdoctoral fellow at the UI. "These clusters are associated with the discovery in human cancers Similar. "